Comment: Barbiturates might improve adverse effects, such as respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates boost metabolism and decrease blood concentrations of TCAs.
pentobarbital will minimize the level or result of disopyramide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.
CYP3A4 inducers may improve the metabolism of clopidogrel to its active metabolite. Keep an eye on people for prospective boost in antiplatelet effects when CYP3A4 inducers are utilised together with clopidogrel
Keep an eye on Closely (1)pentobarbital will lessen the level or outcome of tadalafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the level or impact of isradipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.
pentobarbital will lessen the level or outcome of temsirolimus by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Monoamine oxidase inhibitors (MAOI) may well inhibit barbiturate metabolism and lengthen get more info barbiturate effects; watch intently
Phenytoin and barbiturate blood levels need to be monitored extra frequently if supplied concurrently; effect of barbiturates on phenytoin metabolism claimed to get variable; sodium valproate and valproic acid appear to reduce barbiturate metabolism; keep track of barbiturate blood stages and make correct dosage adjustments as required
pentobarbital will decrease the level or outcome of colchicine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will reduce the extent or outcome of oliceridine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. If coadministration with a CYP3A4 inducer is critical, contemplate growing oliceridine dose until steady drug effects are attained; monitor for signs of opioid withdrawal.
Check Closely (1)pentobarbital will minimize the level or impact of gefitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the level or effect of buspirone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will lessen the level or influence of propafenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.
pentobarbital will minimize the extent or influence of eltrombopag by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Observe.